Aminoglycosides are poorly penetrate the bacterial cell wall. Drug is prescribed orally 4 times a day in severe cases, but is administered intravenous. Distinguish 3 generations of aminoglycosides: I generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. Therefore, their use in mostly local infection in the eyes, ears, skin. If ingestion is practically not absorbed in the gastrointestinal tract and can be applied to pseudomembranous colitis. Bactericidal action of aminoglycosides. In the form of eye ointment is used for blepharitis, conjunctivitis. Rifampicin is rapidly developing resistance of microorganisms. Macrolides - erythromycin, clarithromycin, and Zeta Erythrocyte Sedimentation Rate roksitromitsin (refers display attribute azalides) act on the 50S subunit ribosome and the translocation break - the final step of protein synthesis in the ribosome-max bacteria. With the destruction of the mass of microbial cells Hyperthermia occurs, which indicates a high efficiency are chosen antibiotic and passes quickly when continuation of chemotherapy. Clindamycin is prescribed orally 4 times a day with infectious diseases LORorganov, bone, teeth, joints, of the abdominal cavity caused by susceptible microorganisms. By means of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and trimethoprim. Roksitromitsin and clarithromycin appointed interior, 2 times a day, azithromycin - 1 time per day. For example, tetracyclines, suppressing the normal gut can cause intestinal candidiasis. Well pro-arise in the bone tissue. Linkozamidov side effects: nausea, vomiting, diarrhea, liver damage, skin rashes, neutropenia, thrombocytopenia. As a result, in the place And join other amino acids are formed "Wrong" (non-functional) proteins. Chance of pseudomembranous colitis associated with suppression of normal intestinal microflora Niemi (strong abdominal cramping, diarrhea, bloody stools). coli, Shigella, Sal-Monell, Pseudomonas aeruginosa, Klebsiella, temofilnuyu wand, as here as the cholera vibrio. For display attribute discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 display attribute the Nobel Prize. pylori. Aminoglycosides III generation amikacin, netilmicin similar to the spectrum of action, interaction with gentamicin and tobramycin; differ effective against bacteria resistant to aminoglycosides, I and II generations. Aminoglycosides are used mainly for severe infections caused by susceptible micro-organisms to aminoglycosides (Sepsis, peritonitis, urinary tract infections, pneumonia, wound and burn infection). Aminoglycosides act on the 30S ribosomal subunit. Neomycin is more toxic, is used only locally. Chloramphenicol was appointed interior, and in severe cases, intravenously. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). Side effects of rifampicin: flu-like syndrome, disorders of the function of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. Roksitromitsin (rulid) and clarithromycin, in addition, is prescribed for ulcer-term disease of the stomach and duodenum for eradication of H. Side effects of macrolides: nausea, reversible hearing loss, violation of liver function, allergic reaction. Contraindicated in newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color display attribute mortality here 40%). The reaction of exacerbation is possible with quick action of bactericidal antibiotics ticks. Other side effects: stomatitis, glossitis, nausea, vomiting, diarrhea, rash, optic neuritis, encephalopathy. With infectious eye diseases (conjunctivitis, keratitis, blepharitis), chloramphenicol is used as eye drops or display attribute The use of chloramphenicol is limited by its depressant effect on the blood-creation (there are leukopenia, agranulocytosis, aplastic anemia). Lincomycin is less display attribute and often causes side effects. Kanamycin is used in the stability of Mycobacterium tuberculosis to streptomycin-Mycin. Therefore, tetracyclines are usually appointed interior with drug effective against the fungi Candida (eg, nistati-nom). Therefore sredst Islands, violating the synthesis of folic acid, have inhibitory effect on microorganisms and relatively little effect on the organic mechanism person. Organotropic side effects of antibiotics varied.
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